different between goitrogen vs antithyroid

English

Etymology

Coined some time between 1945 and 1950, from goitre +? -o- +? -gen.

Pronunciation

• IPA^(key): /????t??d??n/, /-?d??n/

Noun

goitrogen (plural goitrogens)

1. Any agent that causes goiter, such as thiouracil.
   • "We have previously shown that treating rats with the reversible goitrogen 6-propyl-2-thiouracil (PTU) from birth to Day 25 increases testis size and sperm production in adulthood by up to 80% and 140%, respectively."
   • "These results suggest that excess iodine induces thyroid involution in goitrogen-treated rats at least partially by apoptosis."

Derived terms

• goitrogenic

References

English

Etymology

Coined in 1908 from anti- +? thyroid.

Adjective

antithyroid (not comparable)

1. (biochemistry) Reducing the production or effects of thyroid hormones.
   • 1946 May 18, E. M. Bavin and D. A. Goodchild, "Antithyroid Activity of Thiouracil Derivatives", in Nature 157, 659-660,

     A RECENT report by Anderson et al. on the antithyroid activity of a series of alkyl derivatives of thiouracil shows that peak activity is reached at the n-propyl compound.

   • 1978, H. Yoshida et al., "Association of serum antithyroid antibodies with lymphocytic infiltration of the thyroid gland: studies of seventy autopsied cases", in The Journal of Clinical Endocrinology and Metabolism 46(6):859-862,

     Postmortem histological examination of the thyroid gland and measurement of serum antithyroid antibodies were performed in 70 patients without overt thyroid disease.

   • 2005 March, D. S. Cooper, "Antithyroid Drugs", in The New England Journal of Medicine 352(9):905-917,

     Antithyroid drugs, which have been in use for more than half a century, remain cornerstones in the management of hyperthyroidism, especially for patients with Graves' disease.

   • 2005, The American Thyroid Association, "Hyperthyroidism",

     Drugs known as antithyroid agents—methimazole (Tapazole®) or propylthiouracil (PTU)—may be prescribed if your doctor chooses to treat the hyperthyroidism by blocking the thyroid gland’s ability to make new thyroid hormone.

Synonyms

• thyrostatic

Translations

References