different between goitrogenic vs goitrogen

English

Adjective

goitrogenic (comparative more goitrogenic, superlative most goitrogenic)

1. Of or pertaining to a goitrogen
   • 1968 July, G. A. Bray, “Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effects of thyrotropin,” in The Clinical Journal of Investigation 47(7): 1640–1647,

     The present studies demonstrate that iodine depletion increases the sensitivity of the thyroid to the goitrogenic effects of thyrotropin.

   • 1948 J. Seifter and W. E. Ehrich, “Goitrogenic Compounds: Pharmacological and Pathological Effects,” Journal of Pharmacology and Experimental Therapeutics 92(3): 303-314

     Seventy-eight compounds were screened for goitrogenic action. Of these, 12 were found to be effective, but only thiouracil, propylthiouracil, 2-amino-thiazole and Dithane were found to be markedly active.

Usage notes

See usage note at antithyroid.

Synonyms

• (of or pertaining to that which reduces the production or effects of thyroid hormones): antithyroid

Derived terms

• goitrogenicity

English

Etymology

Coined some time between 1945 and 1950, from goitre +? -o- +? -gen.

Pronunciation

• IPA^(key): /????t??d??n/, /-?d??n/

Noun

goitrogen (plural goitrogens)

1. Any agent that causes goiter, such as thiouracil.
   • "We have previously shown that treating rats with the reversible goitrogen 6-propyl-2-thiouracil (PTU) from birth to Day 25 increases testis size and sperm production in adulthood by up to 80% and 140%, respectively."
   • "These results suggest that excess iodine induces thyroid involution in goitrogen-treated rats at least partially by apoptosis."

Derived terms

• goitrogenic

References