different between ultrapotent vs resiniferatoxin
ultrapotent
English
Etymology
ultra- +? potent
Adjective
ultrapotent (not comparable)
- Extremely potent, of utmost potency.
ultrapotent From the web:
resiniferatoxin
English
Etymology
From resinifera + toxin, in reference to the plant Euphorbia resinifera (resin spurge), from which it is extracted.
Noun
resiniferatoxin (uncountable)
- (organic chemistry) A naturally occurring ultrapotent capsaicin analogue (having in its pure form a Scoville heat unit measure of 16,000,000,000) that activates the receptor TRPV1 (aka vanilloid receptor 1 or the capsaicin receptor) in a subpopulation of primary afferent sensory neurons involved in nociception.
- 1992, Arpad Szallasi, Peter M. Blumberg, 27: Resiniferatoxin, P. Michael Conn (editor), Neurotoxins, Harcourt Brace Jovanovich (Academic Press), page 368,
- An exciting recent advance in the vanilloid field has been our discovery that resiniferatoxin (RTX), a naturally occurring diterpene combining structural features of the phorbol ester tumor promoters and of capsaicin (see structures in Fig. 1), functions as an ultrapotent capsaicin analog (4—6) and that the esterification of other phorbol-related diterpenes with homovanillic acid at the C-20 position yields synthetic vanilloids of the RTX class with unique spectra of action (7).
- 2010, Pamela Ellsworth, Alan J. Wein, Questions & Answers About Overactive Bladder, Jones and Bartlett Publishers, 2nd Edition, page 98,
- They both cause an initial stimulation and inflammation, capsaicin much more so than resiniferatoxin.
- 2010, George Koob, Michael Le Moal, Richard Thompson (editors), Encyclopedia of Behavioral Neuroscience, Elsevier (Academic Press), page 395,
- In heterologous expression systems, TRPV1 can be activated not only by vanilloid compounds, but also by resiniferatoxin, extracellular protons, and arachidonic acid metabolites.
- 1992, Arpad Szallasi, Peter M. Blumberg, 27: Resiniferatoxin, P. Michael Conn (editor), Neurotoxins, Harcourt Brace Jovanovich (Academic Press), page 368,
Synonyms
- (naturally occurring capsaicin analogue): RTX
Hypernyms
- (naturally occurring capsaicin analogue): diterpene, vanilloid
resiniferatoxin From the web:
- what is resiniferatoxin used for
- can resiniferatoxin kill you
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