different between goitrogenic vs antithyroid

English

Adjective

goitrogenic (comparative more goitrogenic, superlative most goitrogenic)

1. Of or pertaining to a goitrogen
   • 1968 July, G. A. Bray, “Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effects of thyrotropin,” in The Clinical Journal of Investigation 47(7): 1640–1647,

     The present studies demonstrate that iodine depletion increases the sensitivity of the thyroid to the goitrogenic effects of thyrotropin.

   • 1948 J. Seifter and W. E. Ehrich, “Goitrogenic Compounds: Pharmacological and Pathological Effects,” Journal of Pharmacology and Experimental Therapeutics 92(3): 303-314

     Seventy-eight compounds were screened for goitrogenic action. Of these, 12 were found to be effective, but only thiouracil, propylthiouracil, 2-amino-thiazole and Dithane were found to be markedly active.

Usage notes

See usage note at antithyroid.

Synonyms

• (of or pertaining to that which reduces the production or effects of thyroid hormones): antithyroid

Derived terms

• goitrogenicity

English

Etymology

Coined in 1908 from anti- +? thyroid.

Adjective

antithyroid (not comparable)

1. (biochemistry) Reducing the production or effects of thyroid hormones.
   • 1946 May 18, E. M. Bavin and D. A. Goodchild, "Antithyroid Activity of Thiouracil Derivatives", in Nature 157, 659-660,

     A RECENT report by Anderson et al. on the antithyroid activity of a series of alkyl derivatives of thiouracil shows that peak activity is reached at the n-propyl compound.

   • 1978, H. Yoshida et al., "Association of serum antithyroid antibodies with lymphocytic infiltration of the thyroid gland: studies of seventy autopsied cases", in The Journal of Clinical Endocrinology and Metabolism 46(6):859-862,

     Postmortem histological examination of the thyroid gland and measurement of serum antithyroid antibodies were performed in 70 patients without overt thyroid disease.

   • 2005 March, D. S. Cooper, "Antithyroid Drugs", in The New England Journal of Medicine 352(9):905-917,

     Antithyroid drugs, which have been in use for more than half a century, remain cornerstones in the management of hyperthyroidism, especially for patients with Graves' disease.

   • 2005, The American Thyroid Association, "Hyperthyroidism",

     Drugs known as antithyroid agents—methimazole (Tapazole®) or propylthiouracil (PTU)—may be prescribed if your doctor chooses to treat the hyperthyroidism by blocking the thyroid gland’s ability to make new thyroid hormone.

Synonyms

• thyrostatic

Translations

References