different between antagonistic vs spiteful

English

From antagonist +? -ic.

antagonistic (comparative more antagonistic, superlative most antagonistic)

Contending or acting against.
- 1855, Henry Hart Milman, History of Latin Christianity^[1]:
  They were distinct, adverse, even antagonistic.
- 1866, American Journal of Pharmacy and the Sciences Supporting Public Health:
  Though the tephrosia is a powerful agent, and, if carried too far beyond the antagonistic action of the poison, is, I presume, not entirely without danger, I have never known any bad symptoms to arise from its use.
(biochemistry) Relating to an antagonist

From Middle English spytefulle, equivalent to spite +? -ful.

spiteful (comparative spitefuller, superlative spitefullest)

Filled with, or showing, spite; having a desire to annoy or harm.
Synonyms: malignant, malicious

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