Paul Nurse quotes:

At age 11 in 1960, I moved to an academic state secondary school, Harrow County Grammar School for Boys.

Like many students, I found the drudgery of real experiments and the slowness of progress a complete shock, and at my low points I contemplated other alternative careers including study of the philosophy or sociology of science.

I met my wife Anne who was a sociology student, and her influence together with activities associated with the student movement of the time opened up my interests amongst other things into the theatre, art, music, politics and philosophy.

I was never very good at exams, having a poor memory and finding the examination process rather artificial, and there never seemed to be enough time to follow up things that really interested me.

This possibility bothered me as I thought it was not advisable to remain in one academic environment, and the long dark winters in Edinburgh could be rather dismal.

I had a great time investigating the pigments of different mutant fruit flies by following experimental protocols published in Scientific American, and I also remember making my own beetle collection when it was still acceptable to make such collections.

Therefore, I reasoned that study of the cell cycle responsible for the reproduction of cells was important and might even be illuminating about the nature of life.

My parents were born in Norfolk and spent their early years working in the big houses of that rural English county, my mother as a cook and my father as a handyman and chauffeur.

After an extensive interview he arranged for my weaknesses in foreign languages to be over-looked and so I started a Biology degree at Birmingham in 1967.

I decided that the University of Sussex in Brighton was a good place for this work because it had a strong tradition in bacterial molecular genetics and an excellent reputation in biology.

This time at Birmingham turned me into a general biologist, and ever since then I have always tried to take a biological approach to any research project that I have undertaken.

A key issue in developmental biology at that time was the problem of how cells underwent differentiation, with most workers concentrating on explanations in terms of changes in enzyme and gene regulation.

My parents were neither wealthy nor academic, but we lived comfortably and they were always extremely supportive of my academic efforts and aspirations, both at school and university.

During the winter my attention was attracted to the changes in the stars and planets in the sky.

It was during my time at secondary school that I abandoned religion.

Scientific understanding is often beautiful, a profoundly aesthetic experience which gives pleasure not unlike the reading of a great poem.

It has been a privilege to pursue knowledge for its own sake and to see how it might help mankind in more practical ways.

I have an idealistic view of science as a liberalising and progressive force for humanity.

I felt strongly that since the pursuit of good science was so difficult it was essential that the problem being studied was an important one to justify the effort expanded.

Better understanding of the natural world not only enhances all of us as human beings, but can also be harnessed for the better good, leading to improved health and quality of life.

I decided that the University of Sussex in Brighton was a good place for this work because it had a strong tradition in bacterial molecular genetics and an excellent reputation in biology."

Ever since Sir Isaac Newton's times, scientists have worked in the same sort of way: They show a great respect for experiment and observation, They don't cherry pick data, They take a skeptical approach to what they do. And then scientists work together to get a consensus as to what should be believed And that generates very reliable knowledge and that reliable knowledge drives innovation

My main efforts focussed on trying to identify the rate controlling steps during the cell cycle. Crucial for this analysis were wee mutants that were advanced prematurely through the cell cycle and so divided at a reduced cell size.

I was by far the youngest of the family, and at times it was like being an only child.

I am still a keen mountain walker and an enthusiastic glider pilot.

How scientists go about their job: and it's a process, it's a question of asking questions, respecting observation, respecting experiment, having tentative explanations and then testing them.... There is a problem sometimes with how we teach science at schools. Because we sometimes teach it as if it has been chiseled in stone.

I think it was this curiosity about the natural world which awoke my early interest in science.