different between allotope vs allotype

English

Noun

allotope (plural allotopes)

1. A region of an antibody with a non-varying structure.

Related terms

• idiotope

English

Etymology

allo- +? -type

Noun

allotype (plural allotypes)

1. (zoology, taxonomy) A designated paratype of a species (or lower-order taxon) that is the opposite sex of the holotype.
   • 2007, Ivana Karanovic, Candoninae (Ostracoda) from the Pilbara Region in Western Australia, Koninklijke Brill, page 182,

     The allotype female has one T2 deformed (fig. 75D), while the other one is normally developed.

2. (biochemistry) A genetically determined variant of the amino acid sequence of a protein.
   • 2007, I. D. Walker, G. Winter, D. J. Worthington, Chapter 2: Structural Investigations of Peptides and Proteins: I: Primary Structure and Chemical Modification, R. C. Sheppard, Amino Acids, Peptides and Proteins, Volume 8, The Chemical Society, page 145,

     Until recently, different C-region allotypes were explained by allelic genes which each encoded a different but closely related protein sequence.

3. (immunology) An immunoglobulin allotype; the allele of the antibody chains found in an individual.
   • 1996, James W. Goding, Monoclonal Antibodies: Principles and Practice, Academic Press, 3rd Edition, page 102,

     The products of allelic forms of the same gene are known as allotypes. Allotypes are now known for all mouse heavy chains (Stall, 1995). There are no known serologically detectable allotypes of mouse ? chains.

   • 2007, Janardan P. Pandey, 7: Genetics of Immunoglobulins, Gabriel Virella (editor), Medical Immunology, Informa Healthcare, 6th Edition, page 77,

     Since different individuals of the same species may have different allotypes, these determinants can be used as genetic markers.

     The most common technique used for allotype determination is hemagglutination-inhibition.

   • 2009, Julius M. Cruse, Robert E. Lewis, Illustrated Dictionary of Immunology, Taylor & Francis (CRC Press), 3rd Edition, page 32,

     Allotypes were originally defined by antisera that differentiated allelic variants of immunoglobulin (Ig) subclasses. The allotype is due to the existence of different alleles at the genetic locus that determines the expression of a given determinant.

Derived terms

• immunoglobulin allotype

Related terms

• allele
• holotype

Translations