Simon Helberg quotes:

I thought it was going to be a hut in Topanga and Janis Joplin was going to come out, but it's a real doctor... I went to Beverly Hills to meet this midwife; you'd think they'd be in nature.

I walked into the wrong examination room. I'm bad enough at facial recognition... I saw more that day than I cared to. Fortunately, I didn't recognize her from that angle, whoever it was, and I didn't ask. I'm off to a rocky start on the road to fatherhood, but I got a free view.

I was like, I can't believe I get to be in a scene with Meryl Streep [in Florence Foster Jenkins]! And then I was like, but why do I have to play Chopin? It's already going to be intimidating.

I wouldn't wear turtlenecks. That I'm not envious of. But who knows? I might sneak out a few things and hope and pray that no one says, 'Hey, didn't you wear that when you were playing an enormous geek on TV?'

We're going to do a natural birth. At first she was like, 'We should do it at home,' and I said, 'Look, either way, when you go into labor, I will be checking into a hospital... so if you want to come along, come along.

Well, I think that everybody is kind of a nerd at heart.

I don't believe I'll be in the new 'Arrested Development' unless they ask me, in which case, okay! That's how easy I am to get.

Actually, when I was young, I believe I met Nicolas Cage. I think I was probably eight, and I remember seeing him at somebody's house - it was an event and he happened to be there. People would ask me if I was his son, because I looked like him at that point, so I do remember feeling some connection and just wanting to say, like, 'Papa!'

Meryl Streep is so brilliant is because she is so human, and aware as a performer.

I actually struggled through teaching myself to cook because I'm completely ignorant in the kitchen. So I did really macho things like trying to make my own curry. Really hardcore stuff.

I looked at the job of piano accompanist. It's a selfless position and generally they are odd people, according to opera singers I talked to. Just like everybody else, they want more from their life, but now their job is to make others shine.

Im married, so I tend not to hit on every girl.

The weird part is actually, there were so many exceptionally talented people there [ on "MADtv"]. But it was a disaster. I don't think I enjoyed any of it, really. I had a different sensibility.

I was young. I was 23 or 24. I just wasn't a fan of the politics of campaigning - of going into that environment and competing and trying to get into the good graces of the writers.

I did not want to be the accompanist to an operatic star. But I was at a very high level for a 16-year-old, and I maintained that. So really good, but more impressive than classically trained. So I had to take a crash course in classical technique because I really wanted to get away with playing this character [in Florence Foster Jenkins] without people saying, "That's not really accurate."

Everybody has something now. It's become very over-saturated, and it's hard to weed out what's good, what you should watch and what you have time to watch. And Twitter was much less crowded, at the time, and it was an easier way to reach people. So, the combination of having a great video, a lot more access to people through Twitter, and having Kickstarter be this new thing in. We tapped into it, at its inception, and got people interested in it just based on the concept of what Kickstarter was. The timing was right.

Generally people are nice, but it's so weird that it has made me more cautious. Just like anyone else, I like looking around at my environment, but now as I walk down the street I tend to look down.

I always honestly dreamed of coming to Second City in Chicago, although I've never even been there to see a show. But I did a ton of sketch comedy at the Second City in LA, which (at the time, in a different location) wasn't really a theater, it was just a space where you took some classes.

I came in ["MADtv"] kind of late in the season. Some of the producers didn't want me but the network did. It was all (messed up) from the beginning.

I don't mind being recognized, it's just that I have a bit of social anxiety, and this situation has increased it. The idea of having to be 'on' and social at random times can be difficult. I'll be out in the morning, someone comes and takes a picture, and then I discover I have toothpaste on my face.

I had to learn all the pieces backward and forward [to play it in "Florence Foster Jenkins"]. We practiced on weekends. It was very much like being in school, except it was with Meryl Streep. Like, I would go to her apartment and we would practice Mozart's "Queen of the Night."

I met a bunch of people and they said, "We're gonna do a show [Second City]." So we would buy the theater out and do a show, and we did that for five years and we ended up becoming popular. It was before sketch comedy was hipster-time - when you would hand out a flier, people would roll their eyes. Now it's kind of cool.

I wanted to come to Chicago. I also wanted to do "Saturday Night Live." And then I got to a place where I didn't want to do those things anymore.For the sketch comedy thing, I got cast on "MADtv," and that will kill any man's desire to do comedy.

I wanted to move on. I wanted to do acting. The next thing I did after [MADtv] was a good hybrid of that. I did this show with Bob Odenkirk and Derek Waters (creator of Comedy Central's "Drunk History") and it was a little homegrown thing that we shot and then we sold it to HBO. We made a pilot and HBO didn't pick it up, but then we made all these webisodes. This was before streaming stuff online made any sense. (The episodes are available on YouTube). Nobody even knew how to watch things on the internet.

It was like in the film, when I was actually doing a take and wasn't quite sure of the context, and then in the completed film it works beautifully.In the end I didn't know why I felt so shitty doing it, and why it turns out great in the final product. I guess you have to live in that unknown.

It's always nice when someone says that they don't realize it's me on screen, but it would be strange to enter a one story while thinking of another character I do, which is completely different.

It's amazing to watch somebody who is kind of this sleazy, degenerate lothario, sex-crazed guy become sort of a romantic, settled-down man about to have a baby.

It's not really about confidence. It's just something that isn't really in the vocabulary of what goes on at work. The writers write and the actors act.

That is what's disconcerting about working on the show, you can't seem to get an instinct about what works and what doesn't. It happens a lot, and in different ways.

There are bits at the table read that destroy, so much so that we can't wait to do it in taping. And then, no reaction. And then there are times when I can't get the right read on a line in rehearsal, and then the audience howls at it. The strange thing is I still don't know why it happens like that. It's not like afterwards I think, 'Now I know why that worked!'

There are those moments where you realize that your parents or your heroes are human and are fallible. That concept, in and of itself, is something that is dangerous to me, in a good way. It's exciting and scary to meet those people.

There's also these moments when you're like, oh, I really want to do different things. Not instead of this show [The Big Bang Theory]. It's just a hunger to do something else, too.

There's no real escape from the work, but in some ways, if you're as obsessive as I am, it's a sweet little thing we've figured out. You bring your work home and you work 24 hours a day, but it's good.

To me the ambiguity is, maybe our perception of ourselves is always going to be different than somebody else's perception. There will always be that disparity.

We all have those dreams of going back in time and seeing what it was like when our parents were younger. Maybe we don't all have that dream. I don't know. Getting to role play or step back to a different moment in time and see things through a different lens is something that resonated with me, for sure. We don't get to do that, generally, but when the right neurological disorder lines up with the right unstable woman, that moment presents itself. Getting to know where we come from is a really profound way of getting to look at who we are.

What I wanted to do was music, until I was about 16. But it was jazz and rock, never classical music.

When you have this long of a run [in The Big Bang Theory], you don't have to have something happen every episode. Like, Sheldon lost his virginity last season and in the first season he didn't even like girls. So I feel like you can earn that stuff. And that is really fun, because you get to find new layers. It's a testament to the writing.