Santiago Ramon y Cajal quotes:

To know the brain...is equivalent to ascertaining the material course of thought and will, to discovering the intimate history of life in its perpetual duel with external forces.

If a solution fails to appear ... and yet we feel success is just around the corner, try resting for a while. ... Like the early morning frost, this intellectual refreshment withers the parasitic and nasty vegetation that smothers the good seed. Bursting forth at last is the flower of truth.

Buffon said unreservedly, "Genius is simply patience carried to the extreme." To those who asked how he achieved fame he replied: "By spending forty years of my life bent over my writing desk."

If a photographic plate under the center of a lens focused on the heavens is exposed for hours, it comes to reveal stars so far away that even the most powerful telescopes fail to reveal them to the naked eye. In a similar way, time and concentration allow the intellect to perceive a ray of light in the darkness of the most complex problem.

Physical pain is easily forgotten, but a moral chagrin lasts indefinitely.

In summary, all great work is the fruit of patience and perseverance, combined with tenacious concentration on a subject over a period of months or years.

Our novice runs the risk of failure without additional traits: a strong inclination toward originality, a taste for research, and a desire to experience the incomparable gratification associated with the act of discovery itself.

As long as our brain is a mystery, the universe, the reflection of the structure of the brain will also be a mystery.

It is notorious that the desire to live increases as life itself shortens.

There are no small problems. Problems that appear small are large problems that are not understood

To solicit the aid of luck is like stirring muddy water to bring objects submerged at the bottom to the top where they can be seen. Every worker would to well to tempt their good luck. Nevertheless, we should not depend on it too much.

What a cruel irony of fate, to pair together, like Siamese twins united by the shoulders, scientific adversaries of such contrasting character!

Even granting that the genius subjected to the test of critical inspection emerges free from all error, we should consider that everything he has discovered in a given domain is almost nothing in comparison with what is left to be discovered.

Any man could, if he were so inclined, be the sculptor of his own brain.

Every man if he so desires becomes sculptor of his own brain.

Heroes and scholars represent the opposite extremes... The scholar struggles for the benefit of all humanity, sometimes to reduce physical effort, sometimes to reduce pain, and sometimes to postpone death, or at least render it more bearable. In contrast, the patriot sacrifices a rather substantial part of humanity for the sake of his own prestige. His statue is always erected on a pedestal of ruins and corpses... In contrast, all humanity crowns a scholar, love forms the pedestal of his statues, and his triumphs defy the desecration of time and the judgment of history.

I would be the last to deny that the greatest scientific pioneers belonged to an aristocracy of the spirit and were exceptionally intelligent, something that we as modest investigators will never attain, no matter how much we exert ourselves. Nevertheless " I continue to believe that there is always room for anyone with average intelligence " to utilize his energy and " any man could, if he were so inclined, be the sculptor of his own brain, and that even the least gifted may, like the poorest land that has been well-cultivated and fertilized, produce an abundant harvest..

In adult centers the nerve paths are something fixed, ended, immutable. Everything may die, nothing may be regenerated.

In my own view, some advice about what should be known, about what technical education should be acquired, about the intense motivation needed to succeed, and about the carelessness and inclination toward bias that must be avoided is far more useful than all the rules and warnings of theoretical logic.

In the study of this membrane [the retina] I for the first time felt my faith in Darwinism (hypothesis of natural selection) weakened, being amazed and confounded by the supreme constructive ingenuity revealed not only in the retina and in the dioptric apparatus of the vertebrates but even in the meanest insect eye. ... I felt more profoundly than in any other subject of study the shuddering sensation of the unfathomable mystery of life.

Intellectual beauty is sufficient unto itself, and only for it rather than for the future good of humanity does the scholar condemn himself to arduous and painful labors.

It is idle to dispute with old men. Their opinions, like their cranial sutures, are ossified.

Like the enotmologist in search of colorful butterflies, my attention has chased in the gardens of the grey matter cells with delicate and elegant shapes, the mysterious butterflies of the soul, whose beating of wings may one day reveal to us the secrets of the mind.

Nothing inspires more reverence and awe in me than an old man who knows how to change his mind.

That which enters the mind through reason can be corrected. That which is admitted through faith, hardly ever.

The brain is a world consisting of a number of unexplored continents and great stretches of unknown territory.

The worst part is not in making a mistake but in trying to justify it, instead of using it as a heaven-sent warning of our mindlessness or our ignorance.

Unfortunately, nature seems unaware of our intellectual need for convenience and unity, and very often takes delight in complication and diversity.