Francis Collins quotes:

I became an atheist because, as a graduate student studying quantum physics, life seemed to be reducible to second-order differential equations. Mathematics, chemistry and physics had it all. And I didn't see any need to go beyond that.

Successful weight management really means a permanent change in lifestyle - and success in this arena provides that person with a great opportunity to model that behavior for friends and family.

I believe God did intend, in giving us intelligence, to give us the opportunity to investigate and appreciate the wonders of His creation. He is not threatened by our scientific adventures.

I'm enormously interested to see where neuroscience can take us in understanding these complexities of the human brain and how it works, but I do think there may be limits in terms of what science can tell us about what does good and evil mean anyway, and what are those concepts about?

People who are in a position of finding out that they're at risk for some illness, whether it's breast cancer, or heart disease, are afraid to get that information - even though it might be useful to them - because of fears that they'll lose their health insurance or their job.

The brain is the most complicated organ in the universe. We have learned a lot about other human organs. We know how the heart pumps and how the kidney does what it does. To a certain degree, we have read the letters of the human genome. But the brain has 100 billion neurons. Each one of those has about 10,000 connections.

I've never heard God speak out loud to me. That's not an experience I have had.

I think history would say that medical research has, throughout many changes of parties, remained as one of the shining lights of bipartisan agreement, that people are concerned about health for themselves, for their families, for their constituents.

God gave us free will, and we may choose to exercise it in ways that end up hurting other people.

A cardinal principle that we must not stray from - no exceptions - is that your genetic information is your business in terms of who sees it. Nobody should be gaining access to that information without your explicit permission, and nobody should be requiring you to take a genetic test unless you decide that that's what you want to do.

Many people struggle with losing weight and then regaining it. But there is no convincing evidence that the effort to lose weight actually promotes more weight gain in the long run.

I don't have a problem with the concept that miracles might occasionally occur at moments of great significance, where there is a message being transmitted to us by God Almighty. But as a scientist, I set my standards for miracles very high.

Growing up, I was vaguely aware of things that went on in church, because I was in the boys' choir at the local Episcopal church. But I got the clear message that I was supposed to learn music there, and not pay too much attention to the rest of it, and I followed those instructions very carefully.

For delightfully quirky descriptions of bizarre neurological syndromes that teach us a lot about how the brain works, there is no match for Oliver Sacks.

As a Christian, but also as a scientist responsible for overseeing the Human Genome Project, one of my concerns has been the limits on applications of our understanding of the genome. Should there be limits? I think there should. I think the public has expressed their concern about ways this information might be misused.

One must dig deeply into opposing points of view in order to know whether your own position remains defensible. Iron sharpens iron.

If you are in support of in vitro fertilization, then you have to recognize that human embryos are being created in excess of what can be used safely to reimplant for a pregnancy. So they're going to end up being discarded.

It is interesting that the U.S. has this very strong proportion of the population that rejects scientific conclusions about the age of the Earth and about evolutionary relationships between species, including humans.

Proponents of intelligent design don't accept that some of the very complex nanomachines that we have inside ourselves could have come about solely on the basis of natural selection.

My own area of expertise is the genetics of human disease. I was fortunate to be part of the team that found the genes for cystic fibrosis, and Huntington's disease and neurofibromatosis.

Nobody gets argued all the way into becoming a believer on the sheer basis of logic and reason. That requires a leap of faith.

I'm always feeling like I'm lacking wisdom. This reassurance that one can ask God for that and it will happen is certainly reassuring to me.

Science's domain is the natural. If you want to understand the natural world and be sure you're not misleading yourself, science is the way to do it.

When does life begin? When does the soul enter? That's a religious question. Science is not going to be able to help with that.

It's interesting when you read the life of Christ how much of his time he spent healing the sick. There must have been a reason for that - he was modelling for us what it is we are intended to do by following his path.

God is an awesome mathematician and physicist.

I took care of young adults with cystic fibrosis when I was in my residency training and found this to be a disease that was desperately in need of some explanation.

I trained initially as a physical chemist, and then, after becoming interested in biology, I went to medical school and learned how to be a physician. So, I'm a physician scientist.

If I'm walking down the riverbank, and a man is drowning, even if I don't know how to swim very well, I feel this urge that the right thing to do is to try to save that person. Evolution would tell me exactly the opposite: preserve your DNA. Who cares about the guy who's drowning?

Faith is reason plus revelation, and the revelation part requires one to think with the spirit as well as with the mind. You have to hear the music, not just read the notes on the page.

I believe in the literal rising of the body of Christ. It's the cornerstone of my Christian faith.

The shelves of many evangelicals are full of books that point out the flaws in evolution, discuss it only as a theory, and almost imply that there's a conspiracy here to avoid the fact that evolution is actually flawed. All of those books, unfortunately, are based upon conclusions that no reasonable biologist would now accept.

So much of what we are currently seeing as far as human suffering and misery comes from diseases that should have been preventable but were not.

Sometimes you develop a passion for something because of some personal experience.

What faith has not been used by demagogues as a club over somebody's head?

As an atheist evolving to agnosticism, and seeking answers to whether or not belief in God is potentially rational, my life was turned upside down 35 years ago by reading C. S. Lewis's Mere Christianity.

The airman must possess absolutely untroubled nerves.

The blooming of a flower is, in my mind, not a miracle. It's something that we can understand on the basis of molecular biology these days

Science is...a powerful way, indeed - to study the natural world. Science is not particularly effective...in making commentary about the supernatural world. Both worlds, for me, are quite real and quite important. They are investigated in different ways. They coexist. They illuminate each other.

I had the analysis of a million or so SNPs [single nucleotide polymorphisms] just to see what was there. That's partly because I was writing a book about DNA and personalized medicine and I thought it would be a little bit disingenuous to talk about what could be done without actually having the experiment done on yourself.

Yes, evolution by descent from a common ancestor is clearly true. If there was any lingering doubt about the evidence from the fossil record, the study of DNA provides the strongest possible proof of our relatedness to all other living things.

The word 'living' has so many connotations that I'm almost reluctant to try to define it scientifically because it sounds as if I'm then downgrading all the other significances of that word.

We are still working with an incomplete compass. The time is right to bring the full power of genomics to bear on the problem of cancer.

Addressing the conclusions of The God Delusion point by point with the devastating insight of a molecular biologist turned theologian, Alister McGrath dismantles the argument that science should lead to atheism, and demonstrates instead that Dawkins has abandoned his much-cherished rationality to embrace an embittered manifesto of dogmatic atheist fundamentalism.

I'm a pretty informal guy. I ride a Harley.

The God of the Bible is also the God of the genome. He can be worshipped in the cathedral or in the laboratory. His creation is majestic, awesome, intricate, and beautiful.

There are good reasons to believe in God, including the existence of mathematical principles and order in creation. They are positive reasons, based on knowledge, rather than default assumptions based on a temporary lack of knowledge.

By committing the scientific method to religious claims you're committing a logical fallacy

By investigating God's majestic and awesome creation, science can actually be a means of worship.

[Decoding the human genome sequence] is the most significant undertaking that we have mounted so far in an organized way in all of science. I believe that reading our blueprints, cataloguing our own instruction book, will be judged by history as more significant than even splitting the atom or going to the moon.

[The tests agreed] that I was at higher risk than the average person for Type 2 diabetes, which is what my lab works on. In fact, some of the things they were testing for were variants that we had discovered.

The human genome will not help us to understand the spiritual side of humankind, or to know who God is or what love is. The well-heeled couple who decide they want to use genetics to have a child that is a gifted musician may end up with a sullen adolescent who smokes marijuana and doesn't talk to them.

A virus is not just DNA; a virus is also packaged up, covered over with a series of proteins in a nice, elegant, well-compacted form.

A technological advance of a major sort almost always is overestimated in the short run for its consequences - and underestimated in the long run.

Genes are effectively one-dimensional. If you write down the sequence of A, C, G and T, that's kind of what you need to know about that gene. But proteins are three-dimensional. They have to be because we are three-dimensional, and we're made of those proteins. Otherwise we'd all sort of be linear, unimaginably weird creatures.

We give our kids vaccinations. That's a biological enhancement that's considered not just acceptable but actually admirable.

Research is so unpredictable. There are periods when nothing works and all your experiments are a disaster and all your hypotheses are wrong.

Patenting tends to get people's juices flowing when you put the word 'gene' and the word 'patent' in the same sentence. And understandably so. This is stuff we're carrying around - all of us - inside all of our cells. Should somebody be able to lay claim to it?

In my own experience as a physician, I have not seen a miraculous healing, and I don't expect to see one.

If you are looking for a needle in a haystack, and somebody has already cataloged all the straw in the haystack, when you get to that needle you will recognize it's different than what was supposed to be there based on all that computerized haystack information that had been predetermined for you.

Cancer is a disease of the genome. And that's what happens. You make mistakes in a cell somewhere in your body that causes it to start to grow when it should've stopped, and that's cancer. And those mistakes are mistakes of DNA.

I finished up my graduate degree in quantum mechanics, but underwent a bit of a personal crisis, recognizing that I didn't want to do that for the rest of my life. It was too abstract, too far removed from human concerns.

The best diet is the one that can be sustained over the long term, combined with other healthful lifestyle behaviors.

For me, in my Christian belief, prayer is not an opportunity to manipulate God into doing what you want him to. Prayer is an opportunity to have a conversation with God to try to get in tune with what his will is.

There are 15 constants- the gravitational constant, various constants about the strong and weak nuclear force, etc.- that have precise values. If any one of those constants was off by even one part in a million, or in some cases, by one part in a million million, the universe could not have actually come to the point where we see it. Matter would not have been able to coalesce, there would have been no galaxy, stars, planets or people

God is most certainly not threatened by science; He made it all possible.

Scientists must venture outside their comfort zones to show the public how cool - and how important - their work really is.

The tragedy of young-earth creationism is that it takes a relatively recent and extreme view of Genesis, applies to it an unjustified scientific gloss, and then asks sincere and well-meaning seekers to swallow this whole, despite the massive discordance with decades of scientific evidence from multiple disciplines. Is it any wonder that many sadly turn away from faith concluding that they cannot believe in a God who asks for an abandonment of logic and reason?

I think God appreciates that we appreciate his creation

Faith is not the opposite of reason. Faith rests squarely upon reason, but with the added component of revelation.

Prayer is, for me, not an opportunity to ask God to do stuff for me. Prayer is an opportunity to open myself, to try and understand his will, and oftentimes it's a prayer of thanksgiving, and sometimes it's a prayer of supplication, and sometimes it is just worship.

Are we using science in ways that it wasn't intended to, in which case we should be a little careful, or are we using faith in ways that faith wasn't really designed for? There are certain questions that are better answered by one approach than the other, and if you start mixing that up, then you end up in ... conflict.

Evolution, as a mechanism, can be and must be true. But that says nothing about the nature of its author. For those who believe in God, there are reasons now to be more in awe, not less.

What more powerful form of study of mankind could there be than to read our own instruction book?

I took biology in high school and didn't like it at all. It was focused on memorization. ... I didn't appreciate that biology also had principles and logic ... [rather than dealing with a] messy thing called life. It just wasn't organized, and I wanted to stick with the nice pristine sciences of chemistry and physics, where everything made sense. I wish I had learned sooner that biology could be fun as well.

My daughter is a practicing physician so believe me I get a lot of the frustration from her. You get it from patients. For me personally, when I ask my doctor to send me my record, what I get is a scanned PDF of his hard copy! This is not good. It would be hopeless to work with a million people if you had to do this on paper, and one of the reasons this is the right time for this is because of the existence of EHRs.

When a drug comes out [that's broadly prescribed] there are going to start to be a lot of people on it [in a million person cohort] and you might get therefore an early signal of something unexpected that hadn't come through in the clinical trials. And I'm sure [drug companies] would love it if, in fact, FDA, recognizing that, would say, OK, maybe you don't have to do your trial with 30,000 people because we're going to find out shortly after registration because we'll have a lot of people taking the drug and we'll be able to see what happened using PMI.

To get our universe, with all of its potential for complexities or any kind of potential for any kind of life-form, everything has to be precisely defined on this knife edge of improbability. [Y]ou have to see the hands of a creator who set the parameters to be just so because the creator was interested in something a little more complicated than random particles.

When I discover something about the human genome, I experience a sense of awe at the mystery of life, and say to myself, 'Wow, only God knew before.' It is a profoundly beautiful and moving sensation, which helps me appreciate God and makes science even more rewarding for me.

Science's tools will never prove or disprove God's existence.

When you make a breakthrough it is a moment of scientific exhilaration because you have been on this search and seem to have found it. But it is also a moment where I at least feel closeness to the creator in the sense of having now perceived something that no human knew before but God knew all along.

As our closest relatives, they (chimpanzees) tell us special things about what it means to be a primate and, ultimately, what it means to be a human at the DNA level.

All illnesses have some heredity contribution. It's been said that genetics loads the gun and environment pulls the trigger.

It is certainly true in the United States that there is an uneasiness about certain aspects of science, particularly evolution, because it conflicts, in some people's minds, with their sense of how we all came to be. But you know, if you are a believer in God, it's hard to imagine that God would somehow put this incontrovertible evidence in front of us about our relationship to other living organisms and expect us to disbelieve it. I mean, that doesn't make sense at all.

If God is real, and I believe he is, then he is outside of nature. He is, therefore, not limited by the laws of nature in the way that we are.

I'm a serious Christian. I take my faith seriously. I try to practice it every day of the week, not just on Sunday.

I think there are people who's lives have been saved because of the study of the genome.

As a scientist, you're not supposed to make decisions without the data.

The problem [with genetic research] is, we're just starting down this path, feeling our way in the dark. We have a small lantern in the form of a gene, but the lantern doesn't penetrate more than a couple of hundred feet. We don't know whether we're going to encounter chasms, rock walls or mountain ranges along the way. We don't even know how long the path is.

As you kind of get over the anxiety about [science and evolution], it actually adds to your sense of awe about this amazing universe that we live in, it doesn't subtract from it at all.

[Locating, from scratch, the gene related to a disease is like] trying to find a burned-out light bulb in a house located somewhere between the East and West coasts without knowing the state, much less the town or street the house is on.

God decided to create a species with whom he could have fellowship. Who are we to say that evolution was a dumb way to do it? It was an incredibly elegant way to do it.

I'm aware there are certain products that are being advertised - food products - with 'no chemicals whatsoever.' Well, that would be pretty hard to arrange, since everything around us is made up of atoms and molecules - chemicals - including ourselves.

C.S. Lewis had a big influence on me in this spiritual realm - this sort of sense of longing. A longing for a knowledge that is just outside of our reach, a knowledge for a spiritual connection.

What does it take to get people interested, what does it take to get people engaged, what does it take to get them to give a biospecimen? What does it take to get people like Jim [Ostell] to get interested and engaged, versus someone like my mother?

But full sequencing? No. Very hard to interpret. At some point probably we'll all have that opportunity but most of what's there will be stuff that we don't know what to say much about. So it's a great research tool, but for clinical purposes to advise somebody to practice better health maintenance, it's not necessarily gonna be a big one for a while.

It's not like you're closing the old doors and that investigators working away in a laboratories on a unique hypothesis are no longer needed. My gosh, they are indeed. But this becomes a real engine for hypothesis generation and even for proof if you have interventions that you can carry out in this kind of large scale and conduct them in a rigorous way. I guess, yeah, it's different. But it's different in a good way.

A lot of people think PMI is the genome project 2.0. No. This is about all the influences on disease - genetics is in there, but the environment is in there as well, health choices, behaviors, all the factors that are important, otherwise we're not doing what we promised we would do - which is in a holistic way look at how people stay healthy or how do they fall ill.

What wakes me up at night is this next generation and what's happening to them. And they're invariably excited about the science that they're doing, but invariably anxious about where there's a future.

I'm a serious Christian. I take my faith seriously.

A lot of science doesn't require big "ns" but if you're trying to understand something about human health and you're looking at interventions that are not going to be either killing you or making you live forever - they're going to have some tweaking on the outcome - you need big numbers or you don't have enough power.